The Anti-Aging Solution: 5 Simple Steps to Looking and Feeling Young

By Vincent Giampapa, M.D, Ronald Pero, Ph.D. and Marcia Zimmerman, C.N.

Summarized with permission of Wiley (www.wiley.com). All rights reserved.

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Step 5: Make Over Your Skin and Body

Who Is Affected	What You See / Symptoms	What It Means	How to Prevent
Men and Women	Wrinkles	Altered ratio between collagen and elastin, protein cross-linking	Use transdermal CAEs with augmenting nutrients such as niacin, zinc, lipoic acid, and ascorbyl palmitate. Apply daily in the morning or before and after sun exposure.
Women	Fine lines around eyes and lips	Estrogen deficiency	Giampapa recommended an anti-aging face cream with antioxidants and natural estrogen
Men and Women	Chin "wattles," sagging jowls	Free radical damage, drop in collagen synthesis, increased damage to skin proteins, inflammation, low hormone levels	Increase antioxidants, Increase hormones with DEHA
Men and Women	Puffiness around eyes	High Cortisol, poor digestion, dehydration, persistent elevation of Cortisol disrupts homeostasis by interfering with hormone, immune, brain, and nerve function	Drink water, cut alcohol and caffeine. Reduce stress, increase exercise, increase meditation
Men and Women	Concentration of fat in abdomen; pear shape or "beer belly"; rest of body may not be fat	Syndrome X, high LDL and low HDL, increased uric acid, low insulin, receptor insensitivity is known as insulin resistance and is part of a broader syndrome of disorders that include obesity, high blood pressure, and high cholesterol. These four disorders are closely linked and are sometimes referred to as syndrome X	Diet: low in animal fat and refined carbohydrates yet rich in low glycemic foods, healthy monounsaturated and omega-3 polyunsaturated fatty acids, and phytoestrogens which are powerful anti-cancer agents that help balance hormones found in Tan foods
Men	Breast enlargement, fat in upper chest	Low levels of testosterone growth hormone	Anaerobic exercise -- builds strength and releases key anti-aging hormones: insulin, glucagon, human growth hormone (HGH), insulin-like growth factor 1 (IGF-1), and testosterone (also affected by diet). Use transdermal androstenedione with augmenting nutrients such as chrysin, Tribulus terrestris, saw palmetto extract, damiana extract, selenium, zinc, and grapeseed extract to prevent conversion of testosterone into DHT. Apply daily
Women	Breast enlargement	Excess estrogen and progesterone, with higher ratios of progesterone to estrogen
Women	Breast size decreased, sagging	Low estrogen and progesterone, loss of insulin receptor sensitivity, blood sugar elevation	Low estrogen, progesterone, or high testosterone: Use transdermal progesterone, 20 mg applied in the morning and again in the evening.

Prescription for Skin and Body Makeover

Men

• High estrogen: Use progesterone (10 mg) applied twice daily.
• Low DHEA: Use DHEA cream, 15 mg twice daily, or 25 mg oral DHEA twice a day. (Oral doses are higher than topical doses because the liver converts some oral DHEA into inactive metabolites.)
• Low melatonin: You may either use melatonin cream, 3 mg applied before bedtime, or take 1 to 3 mg oral or 500 meg sublingual melatonin just until sleep is restored or saliva melatonin levels are normal.

Women

• Low DHEA: Use DHEA cream 15 mg once daily or 25 mg oral DHEA every other day. (Oral doses are higher than topical doses because the liver converts some oral DHEA into inactive metabolites.)
• Low melatonin: You may either use melatonin cream, 3 mg applied before bedtime, or take 1 to 3 mg oral or 500 meg sublingual melatonin just until sleep is restored or saliva melatonin levels are normal.

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