The Anti-Aging Solution: 5 Simple Steps to Looking and Feeling Young

By Vincent Giampapa, M.D, Ronald Pero, Ph.D. and Marcia Zimmerman, C.N.

Summarized with permission of Wiley (www.wiley.com). All rights reserved.

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Vitamin C and Polyphenols

• Vitamin C reduces cataract risk.
• A natural citrus extract of vitamin C is more bioavailable than ascorbic acid.
• Natural citrus extract of vitamin C may be a more vigorous free radical scavenger than vitamin E in preventing LDL cholesterol oxidation.
• Vitamin C along with selenium inhibits protein glycation and formation of advanced glycation end products.
• Flavonoids protect against several chronic diseases including cardiovascular disease, cerebrovascular disease, and lung and prostate cancers.
• Flavonoids can block prostate-specific antigen and aromatase, which are androgen-regulating proteins implicated in prostate cancer. Flavonoids block the cancer proliferative effects of xenoestro-gens. They have anti-estrogenic and anti-cancer effects. Green tea catechins (EGCG) have potent anti-allergenic activity.
• Green tea catechins have thrombogenic properties that aid weight loss. Grapeseed proanthocyanidin extract protects against DNA fragmentation and increased apoptotic cell death in oral ker-atinocytes of smokers.
• Pycnogenol is an effective anti-inflammatory agent.
• Resveratrol may activate anti-aging enzymes.
• Cranberry juice supplements reverse cholesterol transport, decreasing total cholesterol and LDL.

Daily Prescription for Vitamin C and Polyphenols

Fatty Acid Supplements

• Fatty acids modulate genetic expression of key metabolic enzymes.
• Polyunsaturated fatty acids and vitamin E reduce DNA damage.

Fatty acids make up the lipid bilayer of membranes, and oxidative damage to these lipids causes a dramatic change in cell function including cell differentiation, growth, cytokine adhesion molecule release, and eicosanoid production (anti- or proinflammatory). Listed here are nutrients that are particularly effective in stabilizing cell membranes: Fish oil supplements reduced the need for nonsteroidal anti-inflammatory drug (NSAID) use among patients with rheumatoid arthritis. DHA and fish oil supplements lower triglyceride levels. Fish oil supplements are effective in the treatment of atherosclerosis, thrombosis and embolic events, high triglycerides, hypertension, autoimmune disease, and allergic problems. Omega-3 fatty acid supplements reduce the risk of cardiovascular disease and sudden death in both men and women.

Daily Prescription for Fatty Acid Supplements

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